Ontology highlight
ABSTRACT:
SUBMITTER: Rennie ML
PROVIDER: S-EPMC7332966 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
EMBO reports 20200608 7
The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication stress. A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues. However, the molecular function of these modifications has been unknown for nearly two decades. Here, we find that ubiquitination of FANCD2 acts to increase ID2's affini ...[more]