A novel class of polymeric pH-responsive MRI CEST agents.
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ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC3712501 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
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A novel class of polymeric pH-responsive MRI CEST agents.
Zhang Shanrong S Zhou Kejin K Huang Gang G Takahashi Masaya M Sherry A Dean AD Gao Jinming J
Chemical communications (Cambridge, England) 20130701 57
In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment. ...[more]
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