Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5201433 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yang Xing X Song Xiaolei X Ray Banerjee Sangeeta S Li Yuguo Y Byun Youngjoo Y Liu Guanshu G Bhujwalla Zaver M ZM Pomper Martin G MG McMahon Michael T MT
Contrast media & molecular imaging 20160413 4
A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that t ...[more]