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Developing imidazoles as CEST MRI pH sensors.


ABSTRACT: A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8?ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright © 2016 John Wiley & Sons, Ltd.

SUBMITTER: Yang X 

PROVIDER: S-EPMC5201433 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Developing imidazoles as CEST MRI pH sensors.

Yang Xing X   Song Xiaolei X   Ray Banerjee Sangeeta S   Li Yuguo Y   Byun Youngjoo Y   Liu Guanshu G   Bhujwalla Zaver M ZM   Pomper Martin G MG   McMahon Michael T MT  

Contrast media & molecular imaging 20160413 4


A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that t  ...[more]

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