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Peptide-based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells.

ABSTRACT: Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that, (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.

SUBMITTER: Radford RJ

PROVIDER: S-EPMC3712541 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Peptide-based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells.

Radford Robert J RJ Chyan Wen W Lippard Stephen J SJ

Chemical science 20130801 8

Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that, (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc. ...[more]

PMID: 23878718

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