Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC3715862 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Sun Wei W You Xintian X Gogol-Döring Andreas A He Haihuai H Kise Yoshiaki Y Sohn Madlen M Chen Tao T Klebes Ansgar A Schmucker Dietmar D Chen Wei W
The EMBO journal 20130621 14
The Drosophila melanogaster gene Dscam (Down syndrome cell adhesion molecule) can generate thousands of different ectodomains via mutual exclusive splicing of three large exon clusters. The isoform diversity plays a profound role in both neuronal wiring and pathogen recognition. However, the isoform expression pattern at the global level remained unexplored. Here, we developed a novel method that allows for direct quantification of the alternatively spliced exon combinations from over hundreds o ...[more]