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Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.

ABSTRACT: Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to ?M range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

SUBMITTER: Niemand J

PROVIDER: S-EPMC3716131 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.

Niemand Jandeli J Burger Pieter P Verlinden Bianca K BK Reader Janette J Joubert Annie M AM Kaiser Annette A Louw Abraham I AI Kirk Kiaran K Phanstiel Otto O Birkholtz Lyn-Marie LM

Antimicrobial agents and chemotherapy 20130401 6

Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect. ...[more]

PMID: 23545535

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Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.

Publications

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.

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