Ontology highlight
ABSTRACT:
SUBMITTER: Sathananthan M
PROVIDER: S-EPMC3717878 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Sathananthan Matheni M Farrugia Luca P LP Miles John M JM Piccinini Francesca F Dalla Man Chiara C Zinsmeister Alan R AR Cobelli Claudio C Rizza Robert A RA Vella Adrian A
Diabetes 20130401 8
Exendin-(9,39) is a competitive antagonist of glucagon-like peptide-1 (GLP-1) at its receptor. However, it is unclear if it has direct and unique effects of its own. We tested the hypothesis that exendin-(9,39) and GLP-1-(9,36)amide have direct effects on hormone secretion and β-cell function as well as glucose metabolism in healthy subjects. Glucose containing [3-(3)H]glucose was infused to mimic the systemic appearance of glucose after a meal. Saline, GLP-1-(9,36)amide, or exendin-(9,39) at 30 ...[more]