Ontology highlight
ABSTRACT:
SUBMITTER: Albert B
PROVIDER: S-EPMC3718979 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Albert Benjamin B Mathon Julien J Shukla Ashutosh A Saad Hicham H Normand Christophe C Léger-Silvestre Isabelle I Villa David D Kamgoue Alain A Mozziconacci Julien J Wong Hua H Zimmer Christophe C Bhargava Purnima P Bancaud Aurélien A Gadal Olivier O
The Journal of cell biology 20130701 2
Chromosomes architecture is viewed as a key component of gene regulation, but principles of chromosomal folding remain elusive. Here we used high-throughput live cell microscopy to characterize the conformation and dynamics of the longest chromosome of Saccharomyces cerevisiae (XII). Chromosome XII carries the ribosomal DNA (rDNA) that defines the nucleolus, a major hallmark of nuclear organization. We determined intranuclear positions of 15 loci distributed every ~100 kb along the chromosome, a ...[more]