Ontology highlight
ABSTRACT:
SUBMITTER: Brink MC
PROVIDER: S-EPMC3720725 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brink Maartje C MC Piebes Diewertje G E DG de Groote Marloes L ML Luijsterburg Martijn S MS Casas-Delucchi Corella S CS van Driel Roel R Rots Marianne G MG Cardoso M Cristina MC Verschure Pernette J PJ
PloS one 20130723 7
Methyl-CpG-binding protein 2 (MeCP2) is generally considered to act as a transcriptional repressor, whereas recent studies suggest that MeCP2 is also involved in transcription activation. To gain insight into this dual function of MeCP2, we assessed the impact of MeCP2 on higher-order chromatin structure in living cells using mammalian cell systems harbouring a lactose operator and reporter gene-containing chromosomal domain to assess the effect of lactose repressor-tagged MeCP2 (and separate Me ...[more]