Ontology highlight
ABSTRACT:
SUBMITTER: Crittenden MR
PROVIDER: S-EPMC3723876 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130725 7
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen size. The frequency of myeloid cells does not decline to the level seen in tumor-free mice: we demonstrate that metastatic disease can prevent myeloid cell numbers from returning to baseline, and that tumor recurrence from residual disease correlate ...[more]