Ontology highlight
ABSTRACT:
SUBMITTER: Meerschaert K
PROVIDER: S-EPMC3724457 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Meerschaert Kris K Tun Moe Phyu MP Remue Eline E De Ganck Ariane A Boucherie Ciska C Vanloo Berlinda B Degeest Gisèle G Vandekerckhove Joël J Zimmermann Pascale P Bhardwaj Nitin N Lu Hui H Cho Wonhwa W Gettemans Jan J
Cellular and molecular life sciences : CMLS 20090922 24
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical residues involved in the interaction. Furthermore, peptide and PtdInsP binding of ZO PDZ2 domains are mutually exclusive. Although lipid binding does no ...[more]