Ontology highlight
ABSTRACT:
SUBMITTER: Dobro MJ
PROVIDER: S-EPMC3727925 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20130612 15
The endosomal-sorting complex required for transport (ESCRT) is evolutionarily conserved from Archaea to eukaryotes. The complex drives membrane scission events in a range of processes, including cytokinesis in Metazoa and some Archaea. CdvA is the protein in Archaea that recruits ESCRT-III to the membrane. Using electron cryotomography (ECT), we find that CdvA polymerizes into helical filaments wrapped around liposomes. ESCRT-III proteins are responsible for the cinching of membranes and have b ...[more]