Ontology highlight
ABSTRACT:
SUBMITTER: Schoneberg J
PROVIDER: S-EPMC5198518 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Schöneberg Johannes J Lee Il-Hyung IH Iwasa Janet H JH Hurley James H JH
Nature reviews. Molecular cell biology 20161005 1
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles. This 'reverse' (or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, wh ...[more]