Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues PM
PROVIDER: S-EPMC3728324 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rodrigues Paulo M G PM Grigaravicius Paulius P Remus Martina M Cavalheiro Gabriel R GR Gomes Anielle L AL Rocha-Martins Maurício M Frappart Lucien L Reuss David D McKinnon Peter J PJ von Deimling Andreas A Martins Rodrigo A P RA Frappart Pierre-Olivier PO
PloS one 20130730 7
Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivity, neurological developmental defects and cancer predisposition. However, the functional synergy of Nbn and Atm in different tissues and developmental stages is not yet understood. Here, we show in vivo consequences of conditional inactivation of bot ...[more]