Ontology highlight
ABSTRACT:
SUBMITTER: Baraban EG
PROVIDER: S-EPMC3729479 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Baraban Ezra G EG Morin Jesse B JB Phillips Gillian M GM Phillips Andrew J AJ Strobel Scott A SA Handelsman Jo J
Tetrahedron letters 20130701 31
Endophytes isolated from tropical plants represent a largely untapped reservoir of bioactive secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of the plant pathogen, <i>Pythium ultimum</i>, and purified an active compound using bioassay-guided fractionation. A new nonenolide, (<i>4S,7S,8S,9R</i>)-4-<i>O</i>-succinyl-7,8-dihydroxy-9-heptyl-nonen-9-olide, was isolated and named xyolide. The structure was elucidated by a combination of 1D and 2D NMR methods an ...[more]