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Bioactive PKS-NRPS Alkaloids from the Plant-Derived Endophytic Fungus Xylaria arbuscula.


ABSTRACT: A novel hybrid PKS-NRPS alkaloid, xylarialoid A (1), containing a 13-membered macrocyclic moiety and [5,5,6] fused tricarbocyclic rings, together with ten known cytochalasins (2-11), was isolated from a plant-derived endophytic fungus, Xylaria arbuscula. The chemical structures of all compounds were elucidated using 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculation. Compounds 1-3 and 10 exhibited significant antitumor activities against A549 and Hep G2 cell lines, with IC50 values of 3.6-19.6 μM. In addition, compound 1 showed potent anti-inflammatory activity against LPS-induced nitric oxide (NO) production in macrophage RAW 264.7 cells (IC50, 6.6 μM).

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8746755 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Bioactive PKS-NRPS Alkaloids from the Plant-Derived Endophytic Fungus <i>Xylaria arbuscula</i>.

Wang Ya Y   Zhao Sinan S   Guo Tao T   Li Li L   Li Tantan T   Wang Anqi A   Zhang Dandan D   Wang Yanlei Y   Sun Yi Y  

Molecules (Basel, Switzerland) 20211227 1


A novel hybrid PKS-NRPS alkaloid, xylarialoid A (<b>1</b>), containing a 13-membered macrocyclic moiety and [5,5,6] fused tricarbocyclic rings, together with ten known cytochalasins (<b>2</b>-<b>11</b>), was isolated from a plant-derived endophytic fungus, <i>Xylaria arbuscula</i>. The chemical structures of all compounds were elucidated using 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculation. Compounds <b>1</b>-<b>3</b> and <b>10</b> exhibited s  ...[more]

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