Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Reynaga P
PROVIDER: S-EPMC3731417 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
García-Reynaga Pablo P Zhao Chunqing C Sarpong Richmond R Casida John E JE
Chemical research in toxicology 20130312 4
The highly effective and selective isoxazoline insecticide A1443 is known to potently displace [(3)H]ethynylbicycloorthobenzoate ([(3)H]EBOB) binding to house fly head membranes with an IC50 of 0.2 nM in a manner characteristic of GABA-gated chloride channel antagonists. To further define its mode of action, we prepared phenyl-labeled [(3)H]A1443 as described with a specific activity of 14 Ci/mmol. This new radioligand with an apparent IC50 of about 0.4 nM is poorly displaced by most insecticide ...[more]