Candidate gene studies in hypodontia suggest role for FGF3.

ABSTRACT:

Introduction

The majority of tooth agenesis cases are mild (hypodontia) and typically not associated with the gene mutations linked to oligodontia. From this, we hypothesise that most cases of tooth agenesis fit a polygenic mode of inheritance, where several genes with small effects cause a variety of varying phenotypes.

Materials and methods

In this study, we looked at 18 not typically studied genes in this condition, to ascertain their contribution to hypodontia. Our study subjects consisted of 167 patients with hypodontia and their parents from two cohorts (one from Brazil and one from Turkey). An additional 465 DNA samples (93 cases with hypodontia and 372 controls without family history for tooth agenesis or oral clefts) from Brazil were also available for this study. N

SUBMITTER: Vieira AR 

PROVIDER: S-EPMC3732557 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature