Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC3733225 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
ChemMedChem 20121220 2
PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency in vitro and efficacy in vivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disor ...[more]