Ontology highlight
ABSTRACT:
SUBMITTER: Allison R
PROVIDER: S-EPMC3734076 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Allison Rachel R Lumb Jennifer H JH Fassier Coralie C Connell James W JW Ten Martin Daniel D Seaman Matthew N J MN Hazan Jamilé J Reid Evan E
The Journal of cell biology 20130729 3
Mechanisms coordinating endosomal degradation and recycling are poorly understood, as are the cellular roles of microtubule (MT) severing. We show that cells lacking the MT-severing protein spastin had increased tubulation of and defective receptor sorting through endosomal tubular recycling compartments. Spastin required the ability to sever MTs and to interact with ESCRT-III (a complex controlling cargo degradation) proteins to regulate endosomal tubulation. Cells lacking IST1 (increased sodiu ...[more]