Ontology highlight
ABSTRACT:
SUBMITTER: McCullough J
PROVIDER: S-EPMC4047973 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
McCullough John J Colf Leremy A LA Sundquist Wesley I WI
Annual review of biochemistry 20130318
The endosomal sorting complexes required for transport (ESCRT) pathway was initially defined in yeast genetic screens that identified the factors necessary to sort membrane proteins into intraluminal endosomal vesicles. Subsequent studies have revealed that the mammalian ESCRT pathway also functions in a series of other key cellular processes, including formation of extracellular microvesicles, enveloped virus budding, and the abscission stage of cytokinesis. The core ESCRT machinery comprises B ...[more]