Ontology highlight
ABSTRACT:
SUBMITTER: Waugh RE
PROVIDER: S-EPMC3740191 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Waugh Richard E RE Huang Yu-Shan YS Arif Binish J BJ Bauserman Richard R Palis James J
Experimental hematology 20121130 4
During murine embryogenesis, primitive erythroblasts enter the circulation as immature nucleated cells and progressively mature as a semisynchronous cohort, enucleating between E12.5 and E16.5. In this report, we examine the mechanical properties of these cells to determine how their mechanical development differs from that of definitive erythroid cells, which mature extravascularly in protected marrow microenvironments. Primitive erythroid cells acquire normal membrane deformability by E12.5 (i ...[more]