Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo AC
PROVIDER: S-EPMC3741208 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Figueiredo Ana C AC de Sanctis Daniele D Pereira Pedro José Barbosa PJ
PloS one 20130812 8
The cysteine-less peptidic anticoagulants madanin-1 and madanin-2 from the bush tick Haemaphysalis longicornis are the founding members of the MEROPS inhibitor family I53. It has been previously suggested that madanins exert their functional activity by competing with physiological substrates for binding to the positively charged exosite I (fibrinogen-binding exosite) of α-thrombin. We hereby demonstrate that competitive inhibition of α-thrombin by madanin-1 or madanin-2 involves binding to the ...[more]