Ontology highlight
ABSTRACT:
SUBMITTER: Eisenstein S
PROVIDER: S-EPMC3745543 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Eisenstein Samuel S Coakley Brian A BA Briley-Saebo Karen K Ma Ge G Chen Hui-Ming HM Meseck Marcia M Ward Stephen S Divino Celia C Woo Savio S Chen Shu-Hsia SH Pan Ping-Ying PY
Cancer research 20130327 16
One of the several impediments to effective oncolytic virus therapy of cancer remains a lack of tumor-specific targeting. Myeloid-derived suppressor cells (MDSC) are immature myeloid cells induced by tumor factors in tumor-bearing hosts. The biodistribution kinetics of MDSC and other immune cell types in a murine hepatic colon cancer model was investigated through the use of tracking markers and MRI. MDSCs were superior to other immune cell types in preferential migration to tumors in comparison ...[more]