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A functional link between FOXA1 and breast cancer SNPs.


ABSTRACT: Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor.

SUBMITTER: Katika MR 

PROVIDER: S-EPMC3745646 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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A functional link between FOXA1 and breast cancer SNPs.

Katika Madhumohan R MR   Hurtado Antoni A  

Breast cancer research : BCR 20130218 1


Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor. ...[more]

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