A functional link between FOXA1 and breast cancer SNPs.
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ABSTRACT:
SUBMITTER: Katika MR
PROVIDER: S-EPMC3745646 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A functional link between FOXA1 and breast cancer SNPs.
Katika Madhumohan R MR Hurtado Antoni A
Breast cancer research : BCR 20130218 1
Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor. ...[more]
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