Ontology highlight
ABSTRACT:
SUBMITTER: Schlaitz AL
PROVIDER: S-EPMC3745822 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Schlaitz Anne-Lore AL Thompson James J Wong Catherine C L CC Yates John R JR Heald Rebecca R
Developmental cell 20130801 3
Dynamic interactions between membrane-bound organelles and the microtubule cytoskeleton are crucial to establish, maintain, and remodel the internal organization of cells throughout the cell cycle. However, the molecular nature of these interactions remains poorly understood. We performed a biochemical screen for microtubule-membrane linkers and identified REEP4, a previously uncharacterized endoplasmic reticulum (ER) protein. Depletion of REEP4 and the closely related REEP3 from HeLa cells caus ...[more]