Ontology highlight
ABSTRACT:
SUBMITTER: Hirano Y
PROVIDER: S-EPMC7264229 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Hirano Yasuhiro Y Kinugasa Yasuha Y Osakada Hiroko H Shindo Tomoko T Kubota Yoshino Y Shibata Shinsuke S Haraguchi Tokuko T Hiraoka Yasushi Y
Communications biology 20200601 1
The nuclear envelope (NE) continues to the endoplasmic reticulum (ER). Proper partitioning of NE and ER is crucial for cellular activity, but the key factors maintaining the boundary between NE and ER remain to be elucidated. Here we show that the conserved membrane proteins Lem2 and Lnp1 cooperatively play a crucial role in maintaining the NE-ER membrane boundary in fission yeast Schizosaccharomyces pombe. Cells lacking both Lem2 and Lnp1 caused severe growth defects associated with aberrant ex ...[more]