Ontology highlight
ABSTRACT:
SUBMITTER: Graham SC
PROVIDER: S-EPMC3746937 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Graham Stephen C SC Wartosch Lena L Gray Sally R SR Scourfield Edward J EJ Deane Janet E JE Luzio J Paul JP Owen David J DJ
Proceedings of the National Academy of Sciences of the United States of America 20130730 33
The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 family member. We show that HOPS subunit Vps16 recruits Vps33A to the human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and we present the crystal structure ...[more]