Ontology highlight
ABSTRACT:
SUBMITTER: Smith MA
PROVIDER: S-EPMC3749209 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Smith Mark A MA Blankman Elizabeth E Deakin Nicholas O NO Hoffman Laura M LM Jensen Christopher C CC Turner Christopher E CE Beckerle Mary C MC
PloS one 20130821 8
Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochastic, highly localized strain events, characterized by thinning and elongation within a discrete region of stress fiber. Previous work showed the LIM-domain adaptor protein, zyxin, is essential for repair and stabilization of these sites. Using live im ...[more]