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Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumours, with ?3% meeting current histopathologic criteria for malignancy.

Methods

In this study, we explored the transcriptome of meningiomas using RNA-Seq.

Results

Inversion-mediated fusions between two adjacent genes, NAB2 and STAT6, were detected in one malignant tumour, creating two novel in-frame transcripts that were validated by RT-PCR and Sanger sequencing.

Conclusion

Gene fusions of NAB2-STAT6 were recently implicated in the pathogenesis of solitary fibrous tumours; our study suggested that similar fusions may also have a role in a malignant meningioma with unusual histopathologic features.

SUBMITTER: Gao F

PROVIDER: S-EPMC3749567 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma.

Gao F F Ling C C Shi L L Commins D D Zada G G Mack W J WJ Wang K K

British journal of cancer 20130716 4

<h4>Background</h4>Meningiomas are the most common primary intracranial tumours, with ∼3% meeting current histopathologic criteria for malignancy.<h4>Methods</h4>In this study, we explored the transcriptome of meningiomas using RNA-Seq.<h4>Results</h4>Inversion-mediated fusions between two adjacent genes, NAB2 and STAT6, were detected in one malignant tumour, creating two novel in-frame transcripts that were validated by RT-PCR and Sanger sequencing.<h4>Conclusion</h4>Gene fusions of NAB2-STAT6 ...[more]

PMID: 23860521

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