Dataset Information

Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study.

ABSTRACT:

Background

Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors of GERD in patients with COPD and association between GERD and COPD exacerbation.

Methods

Data were collected from the National Health Insurance Database of Korea. The subjects were 40 years old and older, who had COPD as primary or secondary diagnosis codes and utilized health care resource to receive prescriptions of COPD medication at least twice in 2009. Univariate logistic regression was performed to understand the relationship between COPD and GERD, and multiple logistic regression analysis was performed with adjustment for several confounding factors.

Results

The prevalence of GERD in COPD patients was 28% (39,987/141,057). Old age, female gender, medical aid insurance type, hospitalization, and emergency room (ER) visit were associated with GERD. Most of COPD medications except inhaled muscarinic antagonists were associated with GERD. The logistic regression analysis showed that the presence of GERD was associated with increased risk of hospitalization (OR 1.54, CI 1.50 to 1.58, p<0.001) and frequent ER visits (OR 1.55, CI 1.48 to 1.62, p<0.001).

Conclusions

The prevalence of GERD in patients with COPD was high. Old age, female gender, medical aid insurance type, and many COPD medications except inhaled muscarinic antagonists were associated with GERD. The presence of GERD was associated with COPD exacerbation.

SUBMITTER: Kim J

PROVIDER: S-EPMC3750392 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Publications

Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study.

Kim Jinhee J Lee Jin Hwa JH Kim Yuri Y Kim Kyungjoo K Oh Yeon-Mok YM Yoo Kwang Ha KH Rhee Chin Kook CK Yoon Hyoung Kyu HK Kim Young Sam YS Park Yong Bum YB Lee Sei Won SW Lee Sang Do SD

BMC pulmonary medicine 20130809

<h4>Background</h4>Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors of GERD in patients with COPD and association between GERD and COPD exacerbation.<h4>Methods</h4>Data were collected from the National Health Insurance Database of Korea. The subjects were 40 years old and older, who had COPD ...[more]

PMID: 23927016

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Project description:Traditional Chinese medicine tongue diagnosis can mirror the status of the internal organ, but evidence is lacking regarding the accuracy of tongue diagnosis to gastroesophageal reflux disease (GERD). This study was to investigate the association between GERD and tongue manifestation, and whether tongue imaging could be initial diagnosis of GERD noninvasively.We conducted a cross-sectional, case-controlled observational study at Kaohsiung Chang Gung Memorial Hospital in Taiwan from January 2016 to September 2017. Participants aged over 20 years old with GERD were enrolled and control group without GERD were matched by sex. Tongue imaging were acquired with automatic tongue diagnosis system, then followed by endoscope examination. Nine tongue features were extracted, and a receiver operating characteristic (ROC) curve, analysis of variance, and logistic regression were used.Each group enrolled 67 participants. We found that the saliva amount (P = .009) and thickness of the tongue's fur (P = .036), especially that in the spleen-stomach area (%) (P = .029), were significantly greater in patients with GERD than in those without. The areas under the ROC curve of the amount of saliva and tongue fur in the spleen-stomach area (%) were 0.606 ± 0.049 and 0.615 ± 0.050, respectively. Additionally, as the value of the amount of saliva and tongue fur in the spleen-stomach area (%) increased, the risk of GERD rose by 3.621 and 1.019 times, respectively. The tongue fur in the spleen-stomach area (%) related to severity of GERD from grade 0 to greater than grade B were 51.67 ± 18.72, 58.10 ± 24.60, and 67.29 ± 24.84, respectively.The amount of saliva and tongue fur in the spleen-stomach area (%) might predict the risk and severity of GERD and might be noninvasive indicators of GERD. Further large-scale, multi-center, randomized investigations are needed to confirm the results.Trial registration: NCT03258216, registered August 23, 2017.

Project description:Exertional dyspnea scales (EDS) and health-related quality-of-life questionnaires (HRQoLQs) are used to assess chronic obstructive pulmonary disease (COPD). The GOLD guidelines categorize patients according to either 1 of these 2 domains, the lung function and the frequency of acute exacerbations in the preceding year, however with inconsistent results. Combining EDS and HRQoLQs may yield better results; however, the best combination is unclear. Whether the EDS quantifies the exercise capacity or the dyspnea perception is also unclear. The study was designed to correlate the EDS with exercise capacity and dyspnea perception and to evaluate the best combination of the EDS and HRQoLQ.Three EDS were compared by exercise capacity and Borg scores at rest and during exercise in 57 patients with COPD. Three HRQoLQs were compared by 4 domains of clinical assessments, and 2 types of exercise. The strength of correlation |r| was categorized by quartiles from <0.3 to ?0.6.The EDS was better correlated with exercise capacities (|r|?=?0.29-0.65, P?<?0.05-<0.0001) than with the resting and exertional Borg scores (|r|?=?0.08-0.55, P?=?NS- <0.0001). The EDS were moderately to strongly interrelated, but this correlation was weaker when including Oxygen-cost Diagram (OCD) (with the modified Medical Research Council, mMRC r?=?-0.56, with the baseline dyspnea index, BDI r?=?0.49 vs. mMRC with BDI r?=?-0.73); however, the OCD had the strongest correlation with walking distance (r?=?0.65, vs mMRC r?=?-0.59, BDI r?=?0.5) and peak oxygen uptake (r?=?0.39 vs mMRC r?=?-0.29, BDI r?=?0.36). Among the HRQoLQs, the COPD assessment test (CAT) was most strongly correlated with the St. George Respiratory Questionnaire (SGRQ) (r?=?0.77) and similar to the SGRQ regarding significant correlations with the other instruments (|r|?=?0.29-0.67 vs. 0.36-0.77) but poorly with walking distance (r?=?-0.02). The OCD was mildly correlated with the CAT (r?=?-0.4).The EDS was more related to the exercise capacity than to the dyspnea perception and the CAT was most closely related to the other instruments but poorly with walking distance. The OCD can be used to compensate for this weak correlation. The study suggests using the CAT and the OCD simultaneously when undertaking clinical evaluation of patients with COPD.

Dataset Information

Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study.

Background

Methods

Results

Conclusions

Publications

Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study.

Similar Datasets

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