HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase.
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ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC375155 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
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HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase.
Dong Yuzhi Y Demaria Sandra S Sun Xuming X Santori Fabio R FR Jesdale Bill M BM De Groot Anne S AS Rom William N WN Bushkin Yuri Y
Infection and immunity 20040401 4
Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins. ...[more]
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