Ontology highlight
ABSTRACT:
SUBMITTER: Chiu CQ
PROVIDER: S-EPMC3752161 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Chiu Chiayu Q CQ Lur Gyorgy G Morse Thomas M TM Carnevale Nicholas T NT Ellis-Davies Graham C R GC Higley Michael J MJ
Science (New York, N.Y.) 20130501 6133
γ-aminobutyric acid-mediated (GABAergic) inhibition plays a critical role in shaping neuronal activity in the neocortex. Numerous experimental investigations have examined perisomatic inhibitory synapses, which control action potential output from pyramidal neurons. However, most inhibitory synapses in the neocortex are formed onto pyramidal cell dendrites, where theoretical studies suggest they may focally regulate cellular activity. The precision of GABAergic control over dendritic electrical ...[more]