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Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids.

ABSTRACT: Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate.

SUBMITTER: Kim YW

PROVIDER: S-EPMC3490213 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids.

Kim Yong Wook YW Niphakis Micah J MJ Georg Gunda I GI

The Journal of organic chemistry 20121022 21

Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate. ...[more]

PMID: 23088256

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