Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC4501748 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhao Jianzhi J Li Hanjun H Zhou Rujiang R Ma Gang G Dekker Joseph D JD Tucker Haley O HO Yao Zhengju Z Guo Xizhi X
PloS one 20150714 7
Hair follicle stem cells (HFSCs) in the bugle circularly generate outer root sheath (ORS) through linear proliferation within limited cycles during anagen phases. However, the mechanisms controlling the pace of HFSC proliferation remain unclear. Here we revealed that Foxp1, a transcriptional factor, was dynamically relocated from the nucleus to the cytoplasm of HFSCs in phase transitions from anagen to catagen, coupled with the rise of oxidative stress. Mass spectrum analyses revealed that the S ...[more]