Ontology highlight
ABSTRACT:
SUBMITTER: Hubbard BP
PROVIDER: S-EPMC3755073 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Hubbard Basil P BP Loh Christine C Gomes Ana P AP Li Jun J Lu Quinn Q Doyle Taylor Lg TL Disch Jeremy S JS Armour Sean M SM Ellis James L JL Vlasuk George P GP Sinclair David A DA
Cell cycle (Georgetown, Tex.) 20130701 14
SIRT1 is an NAD (+) -dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction. Understanding how SIRT1 is regulated in vivo could therefore lead to new strategies to treat age-related diseases. SIRT1 forms a stable complex with DBC1, an endogenous inhibitor. Little is known regarding the biochemical nature of SIRT1-DBC1 complex formation, how it is regulated and whether or not it is possible to block ...[more]