Ontology highlight
ABSTRACT:
SUBMITTER: Jung YS
PROVIDER: S-EPMC3755078 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Jung Youn-Sang YS Lee Su-Jin SJ Lee Sun-Hye SH Chung Ji-Yun JY Jung Youn Jin YJ Hwang Sang Hyun SH Ha Nam-Chul NC Park Bum-Joon BJ
Cell cycle (Georgetown, Tex.) 20130701 14
Renal cell carcinomas (RCCs) are frequently occurring genitourinary malignancies in the aged population. A morphological characteristic of RCCs is an irregular nuclear shape, which is used to index cancer grades. Other features of RCCs include the genetic inactivation of the von Hippel-Lindau gene, VHL, and p53 genetic-independent inactivation. An aberrant nuclear shape or p53 suppression has not yet been demonstrated. We examined the effect of progerin (an altered splicing product of the LMNA g ...[more]