Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC3757749 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gao Xuefei X Yang Jian J Tsang Jason C H JC Ooi Jolene J Wu Donghai D Liu Pentao P
Stem cell reports 20130711 2
The modular DNA recognition code of the transcription-activator-like effectors (TALEs) from plant pathogenic bacterial genus Xanthomonas provides a powerful genetic tool to create designer transcription factors (dTFs) targeting specific DNA sequences for manipulating gene expression. Previous studies have suggested critical roles of enhancers in gene regulation and reprogramming. Here, we report dTF activator targeting the distal enhancer of the Pou5f1 (Oct4) locus induces epigenetic changes, re ...[more]