Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC3759693 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Genes & development 20130801 16
Poly-ADP-ribosylation is a unique post-translational modification participating in many biological processes, such as DNA damage response. Here, we demonstrate that a set of Forkhead-associated (FHA) and BRCA1 C-terminal (BRCT) domains recognizes poly(ADP-ribose) (PAR) both in vitro and in vivo. Among these FHA and BRCT domains, the FHA domains of APTX and PNKP interact with iso-ADP-ribose, the linkage of PAR, whereas the BRCT domains of Ligase4, XRCC1, and NBS1 recognize ADP-ribose, the basic u ...[more]