Ontology highlight
ABSTRACT:
SUBMITTER: Hou WH
PROVIDER: S-EPMC6690395 | biostudies-literature | 2019 Apr - Jun
REPOSITORIES: biostudies-literature
Mutation research. Reviews in mutation research 20170920
Poly(ADP-ribosyl)ation (aka PARylation) is a unique protein post-translational modification (PTM) first described over 50 years ago. PARylation regulates a number of biological processes including chromatin remodeling, the DNA damage response (DDR), transcription, apoptosis, and mitosis. The subsequent discovery of poly(ADP-ribose) polymerase-1 (PARP-1) catalyzing DNA-dependent PARylation spearheaded the field of DDR. The expanding knowledge about the poly ADP-ribose (PAR) recognition domains pr ...[more]