Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast.
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ABSTRACT:
SUBMITTER: Skelly DA
PROVIDER: S-EPMC3759725 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast.
Skelly Daniel A DA Merrihew Gennifer E GE Riffle Michael M Connelly Caitlin F CF Kerr Emily O EO Johansson Marnie M Jaschob Daniel D Graczyk Beth B Shulman Nicholas J NJ Wakefield Jon J Cooper Sara J SJ Fields Stanley S Noble William S WS Muller Eric G D EG Davis Trisha N TN Dunham Maitreya J MJ Maccoss Michael J MJ Akey Joshua M JM
Genome research 20130529 9
To better understand the quantitative characteristics and structure of phenotypic diversity, we measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 genetically diverse strains of Saccharomyces cerevisiae. More than 50% of all measured traits varied significantly across strains [false discovery rate (FDR) = 5%]. The structure of phenotypic correlations is complex, with 85% of all traits significantly correlated with at least one other phenotype (median = 6, maximu ...[more]
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