Ontology highlight
ABSTRACT:
SUBMITTER: Tharakaraman K
PROVIDER: S-EPMC3760228 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Tharakaraman Kannan K Raman Rahul R Viswanathan Karthik K Stebbins Nathan W NW Jayaraman Akila A Krishnan Arvind A Sasisekharan V V Sasisekharan Ram R
Cell 20130606 7
Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively switch" its binding from avian to human glycan receptors. Here, we describe a structural framework that outlines a necessary set of H5 HA receptor-binding site (RBS) features required for the H5 HA to quantitatively switch its preference to human receptors. We show here that the same RBS HA mut ...[more]