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Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.


ABSTRACT: Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolving animal lineage thus offers unique perspectives on the level of genome plasticity. It also illuminates issues as fundamental as the mechanisms of intron gain.

SUBMITTER: Denoeud F 

PROVIDER: S-EPMC3760481 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.

Denoeud France F   Henriet Simon S   Mungpakdee Sutada S   Aury Jean-Marc JM   Da Silva Corinne C   Brinkmann Henner H   Mikhaleva Jana J   Olsen Lisbeth Charlotte LC   Jubin Claire C   Cañestro Cristian C   Bouquet Jean-Marie JM   Danks Gemma G   Poulain Julie J   Campsteijn Coen C   Adamski Marcin M   Cross Ismael I   Yadetie Fekadu F   Muffato Matthieu M   Louis Alexandra A   Butcher Stephen S   Tsagkogeorga Georgia G   Konrad Anke A   Singh Sarabdeep S   Jensen Marit Flo MF   Huynh Cong Evelyne E   Eikeseth-Otteraa Helen H   Noel Benjamin B   Anthouard Véronique V   Porcel Betina M BM   Kachouri-Lafond Rym R   Nishino Atsuo A   Ugolini Matteo M   Chourrout Pascal P   Nishida Hiroki H   Aasland Rein R   Huzurbazar Snehalata S   Westhof Eric E   Delsuc Frédéric F   Lehrach Hans H   Reinhardt Richard R   Weissenbach Jean J   Roy Scott W SW   Artiguenave François F   Postlethwait John H JH   Manak J Robert JR   Thompson Eric M EM   Jaillon Olivier O   Du Pasquier Louis L   Boudinot Pierre P   Liberles David A DA   Volff Jean-Nicolas JN   Philippe Hervé H   Lenhard Boris B   Roest Crollius Hugues H   Wincker Patrick P   Chourrout Daniel D  

Science (New York, N.Y.) 20101118 6009


Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolvi  ...[more]

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