GADD34 induces cell death through inactivation of Akt following traumatic brain injury.
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ABSTRACT:
SUBMITTER: Farook JM
PROVIDER: S-EPMC3763442 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
GADD34 induces cell death through inactivation of Akt following traumatic brain injury.
Farook J M JM Shields J J Tawfik A A Markand S S Sen T T Smith S B SB Brann D D Dhandapani K M KM Sen N N
Cell death & disease 20130801
Neuronal cell death contributes significantly to the pathology of traumatic brain injury (TBI) irrespective of the mode or severity of the injury. Activation of a pro-survival protein, Akt, is known to be regulated by an E3 ligase TRAF6 through a process of ubiquitination-coupled phosphorylation at its T308 residue. Here we show that upregulation of a pro-apototic protein, GADD34, attenuates TRAF6-mediated Akt activation in a controlled cortical impact model of TBI in mice. TBI induces the expre ...[more]
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