Ontology highlight
ABSTRACT:
SUBMITTER: Farook JM
PROVIDER: S-EPMC3763442 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cell death & disease 20130801
Neuronal cell death contributes significantly to the pathology of traumatic brain injury (TBI) irrespective of the mode or severity of the injury. Activation of a pro-survival protein, Akt, is known to be regulated by an E3 ligase TRAF6 through a process of ubiquitination-coupled phosphorylation at its T308 residue. Here we show that upregulation of a pro-apototic protein, GADD34, attenuates TRAF6-mediated Akt activation in a controlled cortical impact model of TBI in mice. TBI induces the expre ...[more]