Ontology highlight
ABSTRACT:
SUBMITTER: Wasylishen AR
PROVIDER: S-EPMC3765156 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Oncogene 20110328 34
The ability of Myc to promote cellular transformation is well established; however, a better understanding of the mechanisms through which Myc mediates tumorigenesis is essential for the development of therapeutic approaches to target this potent oncoprotein. Structure-function studies in rodent fibroblast cells have provided the basis for much of our current understanding of these mechanisms. To build on these approaches, we have characterized three novel human cell line models of Myc-dependent ...[more]