Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3766981 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Li LiQi L Jothi Raja R Cui Kairong K Lee Jan Y JY Cohen Tsadok T Gorivodsky Marat M Tzchori Itai I Zhao Yangu Y Hayes Sandra M SM Bresnick Emery H EH Zhao Keji K Westphal Heiner H Love Paul E PE
Nature immunology 20101226 2
The nuclear adaptor Ldb1 functions as a core component of multiprotein transcription complexes that regulate differentiation in diverse cell types. In the hematopoietic lineage, Ldb1 forms a complex with the non-DNA-binding adaptor Lmo2 and the transcription factors E2A, Scl and GATA-1 (or GATA-2). Here we demonstrate a critical and continuous requirement for Ldb1 in the maintenance of both fetal and adult mouse hematopoietic stem cells (HSCs). Deletion of Ldb1 in hematopoietic progenitors resul ...[more]