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Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.

ABSTRACT: A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

SUBMITTER: Yu YY

PROVIDER: S-EPMC3767375 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.

Yu Yi-Yun YY Bi Lei L Georg Gunda I GI

The Journal of organic chemistry 20130610 12

A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs. ...[more]

PMID: 23750615

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