Ontology highlight
ABSTRACT:
SUBMITTER: Sutton LA
PROVIDER: S-EPMC3769528 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Molecular medicine (Cambridge, Mass.) 20130828
Chronic lymphocytic leukemia (CLL) patients assigned to stereotyped subset 4 possess distinctive patterns of intraclonal diversification (ID) within their immunoglobulin (IG) genes. Although highly indicative of an ongoing response to antigen(s), the critical question concerning the precise timing of antigen involvement is unresolved. Hence, we conducted a large-scale longitudinal study of eight subset 4 cases totaling 511 and 398 subcloned IG heavy and kappa sequences. Importantly, we could est ...[more]