Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar M
PROVIDER: S-EPMC4272629 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Chemistry & biology 20141126 12
In patients with chronic lymphocytic leukemia (CLL), a single neoplastic antigen-specific B cell accumulates and overgrows other B cells, leading to immune deficiency. CLL is often treated with drugs that ablate all B cells, leading to further weakening of humoral immunity, and a more focused therapeutic strategy capable of targeting only the pathogenic B cells would represent a significant advance. One approach to this would be to develop synthetic surrogates of the CLL antigens allowing differ ...[more]