Ontology highlight
ABSTRACT:
SUBMITTER: Holl EK
PROVIDER: S-EPMC3771081 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Holl Eda K EK O'Connor Brian P BP Holl T Matt TM Roney Kelly E KE Zimmermann Albert G AG Jha Sushmita S Kelsoe Garnett G Ting Jenny P-Y JP
Journal of immunology (Baltimore, Md. : 1950) 20110404 10
Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for successful vaccination. We report that a new member of the plexin family of molecules, plexin-D1, controls the GC reaction and is required for secondary humoral immune responses. Plexin-D1 was not required for B cell maturation, marginal zone pr ...[more]